Clinical implications of matrix metalloproteinase‐1, ‐3, ‐7, ‐9, ‐12, and plasminogen activator inhibitor‐1 gene polymorphisms in colorectal cancer

Abstract excerpt

BACKGROUND AND AIM: Overexpression of matrix metalloproteinase (MMP)-1, -3, -7, -9, and plasminogen activator inhibitor-1 (PAI-1) are implicated in the invasion and metastasis of colorectal cancer, while MMP-12 provides a protective role against colorectal cancer. The promoter and exon polymorphisms of their genes, which are known to affect the transcription of these genes, were assessed to correlate with...

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