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Genetic polymorphisms of MMP1, MMP3 and MMP7gene promoter and risk of colorectal adenoma

24 Nov 2006

Abstract excerpt

BACKGROUND: Matrix metalloproteinases (MMP) have been shown to play a role in colorectal cancer (CRC). More recently, MMP1, MMP3 and MMP7 functional gene promoter polymorphisms have been found to be associated with CRC occurrence and prognosis. To document the role of MMP polymorphisms in the early step of colorectal carcinogenesis, we investigated their association with colorectal adenoma risk in a case-control...

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PMID: 17125518
DOI: 10.1186/1471-2407-6-270

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