Article
Genetic instability did not lead to p53 mutations in an extremely early-onset breast cancer in a cancer-prone family.
Japanese journal of clinical oncology - 1 Jul 1999
Ishikawa T, Ikeda I, Momiyama N, Yamaoka H, Ishiyama A, Chishima T, Ichikawa Y, Kitamura H, Shuin T, Shimada H
Abstract excerpt
BACKGROUND: A positive family history is a major contributor to risk of development of breast cancer. METHODS: Somatic and germ line mutations of p53 and genetic instability were evaluated for an extremely early-onset breast cancer case in a cancer-prone family. RESULTS: The mode of inheritance in this case was clearly autosomal dominant. DNA replication error was recognized by detecting microsatellite allelic...
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