Article
Intracardiac transplantation of a mixed population of bone marrow cells improves both regional systolic contractility and diastolic relaxation.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation - 1 Feb 2005
Thompson Richard B, van den Bos Ewout J, Davis Bryce H, Morimoto Yoshihisa, Craig Damian, Sutton Brad S, Glower Donald D, Taylor Doris A
Abstract excerpt
BACKGROUND: Pre-clinical and clinical studies suggest that transplantation of bone marrow-derived stem cells can improve global cardiac function. However, no quantitative assessment of regional systolic contraction and correlation with phenotype has been made. Therefore, we used our model of cryoinfarcted rabbit myocardium for intracardiac transplantation of a mixed population of bone marrow-derived cells and...
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