Article
Progenitor cell therapy in a porcine acute myocardial infarction model induces cardiac hypertrophy, mediated by paracrine secretion of cardiotrophic factors including TGFbeta1.
Stem cells and development - 1 Oct 2008
Doyle Brendan, Sorajja Paul, Hynes Brian, Kumar Arun H S, Araoz Phillip A, Stalboerger Paul G, Miller Dylan, Reed Cynthia, Schmeckpeper Jeffrey, Wang Shaohua, Liu Chunsheng, Terzic Andre, Kruger David, Riederer Stephen, Caplice Noel M
Abstract excerpt
Administration of endothelial progenitor cells (EPC) is a promising therapy for post-infarction cardiac repair. However, the mechanisms that underlie apparent beneficial effects on myocardial remodeling are unclear. In a porcine model of acute myocardial infarction, we investigated the therapeutic effects of a mixed population of culture modified peripheral blood mononuclear cells (termed hereafter porcine EPC)....
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