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Article

Molecular genetic dissection of TAF25, an essential yeast gene encoding a subunit shared by TFIID and SAGA multiprotein transcription factors.

Molecular and cellular biology - 1 Oct 2001

Kirchner J, Sanders S L, Klebanow E, Weil P A

Abstract excerpt

We have performed a systematic structure-function analysis of Saccharomyces cerevisiae TAF25, an evolutionarily conserved, single-copy essential gene which encodes the 206-amino-acid TAF25p protein. TAF25p is an integral subunit of both the 15-subunit general transcription factor TFIID and the multisubunit, chromatin-acetylating transcriptional coactivator SAGA. We used hydroxylamine mutagenesis, targeted...

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Identifiers

PMID: 11533254
DOI: 10.1128/MCB.21.19.6668-6680.2001
PMCID: PMC99812

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