Inference of missing SNPs and information quantity measurements for haplotype blocks.

doi:10.1093/bioinformatics/bti261

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Article

Inference of missing SNPs and information quantity measurements for haplotype blocks.

Bioinformatics (Oxford, England) - 1 May 2005

Su Shih-Chieh, Kuo C-C Jay, Chen Ting

Abstract excerpt

MOTIVATION: Missing data in genotyping single nucleotide polymorphism (SNP) spots are common. High-throughput genotyping methods usually have a high rate of missing data. For example, the published human chromosome 21 data by Patil et al. contains about 20% missing SNPs. Inferring missing SNPs us...

Topics

Algorithms
Artifacts
Chromosome Mapping
Computer Simulation
DNA Mutational Analysis
Haplotypes
Information Storage and Retrieval
Linkage Disequilibrium
Models, Genetic
Models, Statistical
Polymorphism, Single Nucleotide
Sequence Analysis, DNA
Software

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