Article
Haplotype reconstruction from genotype data using Imperfect Phylogeny.
Bioinformatics (Oxford, England) - 12 Aug 2004
Halperin Eran, Eskin Eleazar
Abstract excerpt
UNLABELLED: Critical to the understanding of the genetic basis for complex diseases is the modeling of human variation. Most of this variation can be characterized by single nucleotide polymorphisms (SNPs) which are mutations at a single nucleotide position. To characterize the genetic variation between different people, we must determine an individual's haplotype or which nucleotide base occurs at each position...
Topics
- Algorithms
- Chromosome Mapping
- Genetic Variation
- Genetics, Population
- Genotype
- Haplotypes
- Models, Genetic
- Phenotype
- Phylogeny
- Polymorphism, Single Nucleotide
- Recombination, Genetic