Article
An efficient hierarchical generalized linear mixed model for pathway analysis of genome-wide association studies.
Bioinformatics (Oxford, England) - 1 Mar 2011
Wang Lily, Jia Peilin, Wolfinger Russell D, Chen Xi, Grayson Britney L, Aune Thomas M, Zhao Zhongming
Abstract excerpt
MOTIVATION: In genome-wide association studies (GWAS) of complex diseases, genetic variants having real but weak associations often fail to be detected at the stringent genome-wide significance level. Pathway analysis, which tests disease association with combined association signals from a group of variants in the same pathway, has become increasingly popular. However, because of the complexities in genetic data...
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