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Article

Galactose-dependent reversible interaction of Gal3p with Gal80p in the induction pathway of Gal4p-activated genes of Saccharomyces cerevisiae.

Proceedings of the National Academy of Sciences of the United States of America - 4 Mar 1997

Yano K, Fukasawa T

Abstract excerpt

When galactose is added to logarithmically growing culture of the yeast Saccharomyces cerevisiae, a set of genes encoding galactose-metabolizing enzymes (GAL genes) starts to be transcribed within a few minutes. This rapid induction involves a serial interplay of Gal3p, Gal80p, and Gal4p. Recent...

Topics

Adenosine Triphosphate
Blotting, Western
DNA-Binding Proteins
Fungal Proteins
Galactose
Gene Expression Regulation, Fungal
Genes, Fungal
Mutation
Precipitin Tests
Repressor Proteins
Saccharomyces cerevisiae

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Saccharomyces cerevisiae Proteins

Transcription Factors

Transcriptional Activation

Source

Open in PubMed Open full text

Identifiers

PMID: 9050845
DOI: 10.1073/pnas.94.5.1721
PMCID: PMC19983

Genes

GAL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9050845-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Galactose-dependent reversible interaction of Gal3p with Gal80p in the induction pathway of Gal4p-activated genes of Saccharomyces cerevisiae.PMID 9050845Read ↗

Transcriptional control of the GAL/MEL regulon of yeast Saccharomyces cerevisiae: mechanism of galactose-mediated signal transduction.Semantic proximity Read ↗

Multiple metabolic signals influence GAL gene activation by modulating the interaction of Gal80p with the transcriptional activator Gal4p.Semantic proximity Read ↗

Activation of Gal4p by galactose-dependent interaction of galactokinase and Gal80p.Semantic proximity Read ↗

Galactose induction in yeast involves association of Gal80p with Gal1p or Gal3p.Semantic proximity Read ↗

The Gal3p transducer of the GAL regulon interacts with the Gal80p repressor in its ligand-induced closed conformation.Semantic proximity Read ↗

Nondissociation of GAL4 and GAL80 in vivo after galactose induction.Semantic proximity Read ↗

Self-association of the Gal4 inhibitor protein Gal80 is impaired by Gal3: evidence for a new mechanism in the GAL gene switch.Semantic proximity Read ↗

Novel Gal3 proteins showing altered Gal80p binding cause constitutive transcription of Gal4p-activated genes in Saccharomyces cerevisiae.Semantic proximity Read ↗

The mechanism of inducer formation in gal3 mutants of the yeast galactose system is independent of normal galactose metabolism and mitochondrial respiratory function.Semantic proximity Read ↗

Replacement of a conserved tyrosine by tryptophan in Gal3p of Saccharomyces cerevisiae reduces constitutive activity: implications for signal transduction in the GAL regulon.Semantic proximity Read ↗

Purification and characterization of the yeast negative regulatory protein GAL80.Semantic proximity Read ↗

Multiple Conformations of Gal3 Protein Drive the Galactose Induced Allosteric Activation of the GAL Genetic Switch of Saccharomyces cerevisiaeSemantic proximity Read ↗

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