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Article

Transcriptional control of the GAL/MEL regulon of yeast Saccharomyces cerevisiae: mechanism of galactose-mediated signal transduction.

Molecular microbiology - 1 Jun 2001

Bhat P J, Murthy T V

Abstract excerpt

In the yeast Saccharomyces cerevisiae, the interplay between Gal3p, Gal80p and Gal4p determines the transcriptional status of the genes needed for galactose utilization. The interaction between Gal80p and Gal4p has been studied in great detail; however, our understanding of the mechanism of Gal3p in transducing the signal from galactose to Gal4p has only begun to emerge recently. Historically, Gal3p was believed...

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Source

Identifiers

PMID: 11401712
DOI: 10.1046/j.1365-2958.2001.02421.x

Genes

GAL

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transcriptional control of the GAL/MEL regulon of yeast Saccharomyces cerevisiae: mechanism of galactose-mediated signal transduction.PMID 11401712Read ↗

Replacement of a conserved tyrosine by tryptophan in Gal3p of Saccharomyces cerevisiae reduces constitutive activity: implications for signal transduction in the GAL regulon.Semantic proximity Read ↗

Galactose-dependent reversible interaction of Gal3p with Gal80p in the induction pathway of Gal4p-activated genes of Saccharomyces cerevisiae.Semantic proximity Read ↗

Novel Gal3 proteins showing altered Gal80p binding cause constitutive transcription of Gal4p-activated genes in Saccharomyces cerevisiae.Semantic proximity Read ↗

Growth-related model of the GAL system in Saccharomyces cerevisiae predicts behaviour of several mutant strains.Semantic proximity Read ↗

Multiple metabolic signals influence GAL gene activation by modulating the interaction of Gal80p with the transcriptional activator Gal4p.Semantic proximity Read ↗

Analysis of the GAL3 signal transduction pathway activating GAL4 protein-dependent transcription in Saccharomyces cerevisiae.Semantic proximity Read ↗

Stochastic galactokinase expression underlies GAL gene induction in a GAL3 mutant of Saccharomyces cerevisiae.Semantic proximity Read ↗

The Gal3p transducer of the GAL regulon interacts with the Gal80p repressor in its ligand-induced closed conformation.Semantic proximity Read ↗

Activation of Gal4p by galactose-dependent interaction of galactokinase and Gal80p.Semantic proximity Read ↗

The mechanism of inducer formation in gal3 mutants of the yeast galactose system is independent of normal galactose metabolism and mitochondrial respiratory function.Semantic proximity Read ↗

Epigenetics of the yeast galactose genetic switch.Semantic proximity Read ↗

Galactose induction in yeast involves association of Gal80p with Gal1p or Gal3p.Semantic proximity Read ↗

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