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Article

Activation of Gal4p by galactose-dependent interaction of galactokinase and Gal80p.

Science (New York, N.Y.) - 14 Jun 1996

Zenke F T, Engles R, Vollenbroich V, Meyer J, Hollenberg C P, Breunig K D

Abstract excerpt

Yeast galactokinase (Gal1p) is an enzyme and a regulator of transcription. In addition to phosphorylating galactose, Gal1p activates Gal4p, the activator of GAL genes, but the mechanism of this regulation has been unclear. Here, biochemical and genetic evidence is presented to show that Gal1p activates Gal4p by direct interaction with the Gal4p inhibitor Gal80p. Interaction requires galactose, adenosine...

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Source

Identifiers

PMID: 8658143
DOI: 10.1126/science.272.5268.1662

Genes

GAL

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Activation of Gal4p by galactose-dependent interaction of galactokinase and Gal80p.PMID 8658143Read ↗

Galactose induction in yeast involves association of Gal80p with Gal1p or Gal3p.Semantic proximity Read ↗

Sites for interaction between Gal80p and Gal1p in Kluyveromyces lactis: structural model of galactokinase based on homology to the GHMP protein family.Semantic proximity Read ↗

Galactose-dependent reversible interaction of Gal3p with Gal80p in the induction pathway of Gal4p-activated genes of Saccharomyces cerevisiae.Semantic proximity Read ↗

Transcriptional control of the GAL/MEL regulon of yeast Saccharomyces cerevisiae: mechanism of galactose-mediated signal transduction.Semantic proximity Read ↗

Nondissociation of GAL4 and GAL80 in vivo after galactose induction.Semantic proximity Read ↗

GAL4 mutations that separate the transcriptional activation and GAL80-interactive functions of the yeast GAL4 protein.Semantic proximity Read ↗

Gal80 proteins of Kluyveromyces lactis and Saccharomyces cerevisiae are highly conserved but contribute differently to glucose repression of the galactose regulon.Semantic proximity Read ↗

Multiple metabolic signals influence GAL gene activation by modulating the interaction of Gal80p with the transcriptional activator Gal4p.Semantic proximity Read ↗

Purification and characterization of the yeast negative regulatory protein GAL80.Semantic proximity Read ↗

Replacement of a conserved tyrosine by tryptophan in Gal3p of Saccharomyces cerevisiae reduces constitutive activity: implications for signal transduction in the GAL regulon.Semantic proximity Read ↗

The Gal3p transducer of the GAL regulon interacts with the Gal80p repressor in its ligand-induced closed conformation.Semantic proximity Read ↗

Gal80 dimerization and the yeast GAL gene switch.Semantic proximity Read ↗

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