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Article

No evidence of mutations in the P450 aromatase gene in patients with polycystic ovary syndrome.

Human reproduction (Oxford, England) - 1 Apr 2005

Söderlund D, Canto P, Carranza-Lira S, Méndez J P

Abstract excerpt

BACKGROUND: Etiology and inheritance pattern in polycystic ovary syndrome (PCOS) remain uncertain. Granulosa cells from follicles of women with PCOS have little, if any, aromatase (encoded by the CYP19 gene) activity; follicles contain low levels of estradiol, P450arom mRNA and aromatase stimulating bioactivity. Mice with targeted disruption of the CYP19 gene present cystic follicles. It has been proposed that...

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Identifiers

PMID: 15695318
DOI: 10.1093/humrep/deh690

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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No evidence of mutations in the P450 aromatase gene in patients with polycystic ovary syndrome.PMID 15695318Read ↗

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