Article

The Aromatase Excess Syndrome Is Associated with Feminization of Both Sexes and Autosomal Dominant Transmission of Aberrant P450 Aromatase Gene Transcription

1998-04-01

Abstract excerpt

Increased extraglandular aromatization has been reported as the cause of familial gynecomastia.We studied a kindred with aromatase excess inherited in an autosomal dominant manner, in which affected males had heterosexual precocity and/or gynecomastia, and affected females had isosexual precocity and/or macromastia.The propositus was a 9-yr-old boy with gynecomastia.His 7.5-yr-old sister had precocious puberty, an...

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Literature Corpus work: f414976d-7615-596b-9ea3-772b382038ba
DOI: 10.1210/jc.83.4.1348

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