Article
A common polymorphism in the human aromatase gene alters the risk for polycystic ovary syndrome and modifies aromatase activity in vitro.
Molecular human reproduction - 1 Jun 2011
Wang Hui, Li Qiaoli, Wang Teng, Yang Guizhong, Wang Ying, Zhang Xiaoping, Sang Qing, Wang Huan, Zhao Xinzhi, Xing Qinghe, Shi Juanzi, He Lin, Wang Lei
Abstract excerpt
Aromatase is a key enzyme involved in estradiol and estrone biosynthesis. Given that polymorphisms of the CYP19A1 gene encoding aromatase have been correlated with plasma testosterone levels, CYP19A1 may therefore act as a genetic modifier of the hyperandrogenic phenotype of polycystic ovary syndrome (PCOS). However, no functional CYP19A1 polymorphisms that predict the risk of PCOS have been identified. We...
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