Article
The Aromatase Cytochrome P-450 and Its Clinical Impact
1 Jan 2002
Abstract excerpt
Cytochrome P-450 aromatase (P450arom), the key enzyme for estrogen biosynthesis, is encoded by a single gene, namely the CYP19 gene, localized on 15q21.2. The human CYP19 gene spans about 123 kb with a coding region of 9 exons (about 30 kb, exon II-exon X). Although there are a number of alternative first exons and nine different transcriptional start sides with individual promoters that permit tissue-specific...