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Lysyl Oxidase Activity Is Required for Ordered Collagen Fibrillogenesis by Tendon Cells

16 May 2015

Abstract excerpt

Lysyl oxidases (LOXs) are a family of copper-dependent oxido-deaminases that can modify the side chain of lysyl residues in collagen and elastin, thereby leading to the spontaneous formation of non-reducible aldehyde-derived interpolypeptide chain cross-links. The consequences of LOX inhibition in producing lathyrism are well documented, but the consequences on collagen fibril formation are less clear. Here we...

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PMID: 25979340
DOI: 10.1074/jbc.m115.641670

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