Article
Protein-4.2 association with band 3 (AE1, SLCA4) in Xenopus oocytes: effects of three natural protein-4.2 mutations associated with hemolytic anemia.
Blood - 15 May 2005
Toye Ashley M, Ghosh Sandip, Young Mark T, Jones Graham K, Sessions Richard B, Ramaugé Martine, Leclerc Philippe, Basu Joyoti, Delaunay Jean, Tanner Michael J A
Abstract excerpt
We have investigated the effects of coexpression of protein 4.2 and three protein-4.2 variants with band 3 in the Xenopus oocyte expression system. Normal protein 4.2 increased band-3-specific chloride transport in the oocytes. Protein 4.2 also coimmunoprecipitated with band 3 and colocalized with band 3 at the oocyte plasma membrane. The increase in band-3-mediated chloride transport and coimmunoprecipitation of...
Topics
- Anemia, Hemolytic
- Animals
- Anion Exchange Protein 1, Erythrocyte
- Blood Proteins
- Cell Membrane
- Cytoskeletal Proteins
- Humans
- Immunoprecipitation
- Membrane Proteins
- Microscopy, Confocal
- Models, Molecular
- Mutation