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Article

Investigating the key membrane protein changes during in vitro erythropoiesis of protein 4.2 (-) cells (mutations Chartres 1 and 2).

Haematologica - 1 Aug 2010

van den Akker Emile, Satchwell Timothy J, Pellegrin Stephanie, Flatt Joanna F, Maigre Michel, Daniels Geoff, Delaunay Jean, Bruce Lesley J, Toye Ashley M

Abstract excerpt

BACKGROUND: Protein 4.2 deficiency caused by mutations in the EPB42 gene results in hereditary spherocytosis with characteristic alterations of CD47, CD44 and RhAG. We decided to investigate at which stage of erythropoiesis these hallmarks of protein 4.2 deficiency arise in a novel protein 4.2 patient and whether they cause disruption to the band 3 macrocomplex. DESIGN AND METHODS: We used immunoprecipitations...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20179084
DOI: 10.3324/haematol.2009.021063
PMCID: PMC2913075

Genes

CD44
CD47
EPB42

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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