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Article

Absence of CD47 in protein 4.2-deficient hereditary spherocytosis in man: an interaction between the Rh complex and the band 3 complex

13 May 2002

Abstract excerpt

We present data on a patient of South Asian origin with recessive hereditary spherocytosis (HS) due to absence of protein 4.2 [4.2 (-) HS]. Protein 4.2 cDNA sequence analysis showed the presence of a novel 41-bp frameshift deletion that predicts a truncated peptide designated protein 4.2 Hammersmith. Quantitative reverse transcription-polymerase chain reaction indicated that the mutant mRNA was unstable....

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Identifiers

PMID: 12176912
DOI: 10.1182/blood-2002-03-0706

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Related research

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Absence of CD47 in protein 4.2-deficient hereditary spherocytosis in man: an interaction between the Rh complex and the band 3 complexPMID 12176912Read ↗

Evidence that the red cell skeleton protein 4.2 interacts with the Rh membrane complex member CD47.Semantic proximity Read ↗

Investigating the key membrane protein changes during in vitro erythropoiesis of protein 4.2 (-) cells (mutations Chartres 1 and 2).Semantic proximity Read ↗

Hematologically important mutations: band 3 and protein 4.2 variants in hereditary spherocytosis.Semantic proximity Read ↗

Duplication of 10 nucleotides in the erythroid band 3 (AE1) gene in a kindred with hereditary spherocytosis and band 3 protein deficiency (band 3PRAGUE).Semantic proximity Read ↗

Protein 4.2: a complex linker.Semantic proximity Read ↗

Protein 4.2 is critical to CD47-membrane skeleton attachment in human red cells.Semantic proximity Read ↗

Band 3 Tuscaloosa: Pro327----Arg327 substitution in the cytoplasmic domain of erythrocyte band 3 protein associated with spherocytic hemolytic anemia and partial deficiency of protein 4.2.Semantic proximity Read ↗

Total absence of protein 4.2 and partial deficiency of band 3 in hereditary spherocytosis.Semantic proximity Read ↗

Band 3 Courcouronnes (Ser667Phe): a trafficking mutant differentially rescued by wild-type band 3 and glycophorin A.Semantic proximity Read ↗

Band 4.2 abnormalities in human red cells.Semantic proximity Read ↗

Heterogenous band 3 deficiency in hereditary spherocytosis related to different band 3 gene defects.Semantic proximity Read ↗

Protein 4.2 interaction with hereditary spherocytosis mutants of the cytoplasmic domain of human anion exchanger 1.Semantic proximity Read ↗

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