Protein 4.2 Komatsu (D175Y) associated with the lack of interaction with ankyrin in human red blood cells.

doi:10.1016/j.bcmd.2006.11.004

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Article

Protein 4.2 Komatsu (D175Y) associated with the lack of interaction with ankyrin in human red blood cells.

Blood cells, molecules & diseases - 1 Jan 2000

Su Yang, Ding Yu, Jiang Ming, Hu Xiaojian, Zhang Zhihong

Abstract excerpt

Membrane skeletal proteins play an important role in regulating the shape and function of the human red blood cell. Protein 4.2 interacts with cytoplasmic domain of band 3 (CDB3) and ankyrin for association between the skeleton network and the membrane. The deficiency of protein 4.2 may result in hereditary spherocytosis. In order to explore the molecular mechanism of the linkage of protein 4.2 Komatsu (D175Y)...

Topics

Anion Exchange Protein 1, Erythrocyte
Ankyrins
Binding Sites
Cytoskeletal Proteins
Erythrocyte Membrane
Erythrocytes
Humans
Membrane Proteins
Mutation
Protein Binding
Protein Structure, Tertiary
Recombinant Proteins
Structure-Activity Relationship

Source

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Identifiers

PMID: 17188914
DOI: 10.1016/j.bcmd.2006.11.004

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