Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Array-based mutation detection of BRCA1 using direct probe/target hybridization.

Analytical biochemistry - 15 Feb 2005

Yim Seong-Chun, Park Hyun Gyu, Chang Ho Nam, Cho Dae-Yeon

Abstract excerpt

We describe here an efficient microarray-based multiplex assay to detect Korean-specific mutations in breast cancer susceptibility gene BRCA1 using direct probe/target hybridization. Allele-specific oligonucleotides were covalently immobilized on an aldehyde-activated glass slide to prepare an oligonucleotide chip. From a wild-type sample, a two-step method was used to generate labeled multiplex polymerase chain...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to BRCA1 Protein
Share to Breast Neoplasms
Share to DNA Mutational Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Testing

Share to Nucleic Acid Hybridization

Share to Oligonucleotide Array Sequence Analysis

Share to Oligonucleotide Probes

Source

Identifiers

PMID: 15691514
DOI: 10.1016/j.ab.2004.11.034

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Array-based mutation detection of BRCA1 using direct probe/target hybridization.PMID 15691514Read ↗

SNPs detection by a single-strand specific nuclease on a PNA zip-code microarray.Semantic proximity Read ↗

A low-cost hydrogel chip for SNP typing by the incorporation of Cy5-dCTP into label-free allele-specific probes hybridizing to gel-immobilized targets.Semantic proximity Read ↗

Microarray-based detection of Korean-specific BRCA1 mutations.Semantic proximity Read ↗

Detection of heterozygous mutations in BRCA1 using high density oligonucleotide arrays and two-colour fluorescence analysis.Semantic proximity Read ↗

Microarray-based method for genotyping of functional single nucleotide polymorphisms using dual-color fluorescence hybridization.Semantic proximity Read ↗

Highly specific detection of genetic modification events using an enzyme-linked probe hybridization chip.Semantic proximity Read ↗

Oligonucleotide chip for the diagnosis of HNF-1 alpha mutations.Semantic proximity Read ↗

Designed hybridization properties of DNA-gold nanoparticle conjugates for the ultraselective detection of a single-base mutation in the breast cancer gene BRCA1.Semantic proximity Read ↗

High-throughput mutation detection method to scan BRCA1 and BRCA2 based on heteroduplex analysis by capillary array electrophoresis.Semantic proximity Read ↗

Improved DNA microarray detection sensitivity through immobilization of preformed in solution streptavidin/biotinylated oligonucleotide conjugates.Semantic proximity Read ↗

Gold nanoparticle-based label-free detection of BRCA1 mutations utilizing DNA ligation on DNA microarray.Semantic proximity Read ↗

A low density microarray method for the identification of human papillomavirus type 18 variants.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.