Article
Beta2-microglobulin isoforms display an heterogeneous affinity for type I collagen.
Protein science : a publication of the Protein Society - 1 Mar 2005
Giorgetti Sofia, Rossi Antonio, Mangione Palma, Raimondi Sara, Marini Sara, Stoppini Monica, Corazza Alessandra, Viglino Paolo, Esposito Gennaro, Cetta Giuseppe, Merlini Giampaolo, Bellotti Vittorio
Abstract excerpt
It has been claimed that beta2-microglobulin (beta2-m) interacts with type I and type II collagen, and this property has been linked to the tissue specificity of the beta2-m amyloid deposits that target the osteo-articular system. The binding parameters of the interaction between collagen and beta2-m were determined by band shift electrophoresis and surface plasma resonance by using bovine collagen of type I and...
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