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Article

Properties of some variants of human beta2-microglobulin and amyloidogenesis.

The Journal of biological chemistry - 5 Mar 2004

Corazza Alessandra, Pettirossi Fabio, Viglino Paolo, Verdone Giuliana, Garcia Julian, Dumy Pascal, Giorgetti Sofia, Mangione Palma, Raimondi Sara, Stoppini Monica, Bellotti Vittorio, Esposito Gennaro

Abstract excerpt

Three variants of human beta(2)-microglobulin (beta(2)-m) were compared with wild-type protein. For two variants, namely the mutant R3Abeta(2)-m and the form devoid of the N-terminal tripeptide (DeltaN3beta(2)-m), a reduced unfolding free energy was measured compared with wild-type beta(2)-m, whereas an increased stability was observed for the mutant H31Ybeta(2)-m. The solution structure could be determined by...

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Identifiers

PMID: 14660575
DOI: 10.1074/jbc.M310779200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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