Article
LT(K63/R72), a new mutant of Escherichia coli heat-labile enterotoxin, exhibits characteristics more similar to LT(K63) than LT(R72).
Acta biochimica et biophysica Sinica - 1 Feb 2005
Feng Qiang, Yang Jun, Luo Ping, Zhang Wei-Jun, Zou Quan-Ming
Abstract excerpt
LT(K63), a non-toxic mutant and LT(R72), a low toxic mutant of E. coli heat-labile enterotoxin are frequently used mucosal adjuvants. In many cases, the adjuvanticity of LT(K63) is lower than that of LT(R72), but LT(K63), which induces a mixed Th1/Th2 response, exhibits a higher level of protection than LT(R72) which induces a polarized Th2-type response. To utilize the advantages of both adjuvants, a...
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