Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Escherichia coli LTB26 mutant enhances immune responses to rotavirus antigen VP8 in a mouse model.

Molecular immunology - 1 Sept 2024

Shi Qinlin, Wang Qiujuan, Shen Yanxi, Chen Sijing, Gan Sijie, Lin Tao, Song Fangzhou, Ma Yongping

Abstract excerpt

Adjuvant is a major supplementary component of vaccines to boost adaptive immune responses. To select an efficient adjuvant from the heat-labile toxin B subunit (LTB) of E. coli, four LTB mutants (numbered LTB26, LTB34, LTB57, and LTB85) were generated by multi-amino acid random replacement. Mice have been intranasally vaccinated with human rotavirus VP8 admixed. Among the four mutants, enzyme-linked...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adjuvants, Immunologic
Share to Antigens, Viral

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Bacterial Toxins

Share to Enterotoxins

Share to Immunity, Mucosal

Share to Rotavirus

Share to Rotavirus Infections

Share to Rotavirus Vaccines

Source

Identifiers

PMID: 39004021
DOI: 10.1016/j.molimm.2024.07.001

Genes

LTB
BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Escherichia coli LTB26 mutant enhances immune responses to rotavirus antigen VP8 in a mouse model.PMID 39004021Read ↗

Mutant Escherichia coli heat-labile enterotoxin [LT(R192G)] enhances protective humoral and cellular immune responses to orally administered inactivated influenza vaccine.Semantic proximity Read ↗

Escherichia coli heat-labile enterotoxin promotes protective Th17 responses against infection by driving innate IL-1 and IL-23 production.Semantic proximity Read ↗

Genetically manipulated bacterial toxin as a new generation mucosal adjuvant.Semantic proximity Read ↗

Designing a novel multi-epitope vaccine to evoke a robust immune response against pathogenic multidrug-resistant Enterococcus faecium bacteriumSemantic proximity Read ↗

A Reverse Vaccinology and Immunoinformatic Approach for the Designing of a Novel mRNA Vaccine Against Stomach Cancer Targeting the Potent Pathogenic Proteins of Helicobacter pyloriSemantic proximity Read ↗

Adjuvant selection regulates gut migration and phenotypic diversity of antigen-specific CD4+ T cells following parenteral immunization.Semantic proximity Read ↗

Regulation of Host Immune Response against Enterobacter cloacae Proteins via Computational mRNA Vaccine Design through Transcriptional ModificationSemantic proximity Read ↗

Adjuvant activity of a nontoxic mutant of Escherichia coli heat-labile enterotoxin on systemic and mucosal immune responses elicited against a heterologous antigen carried by a live Salmonella enterica serovar Typhimurium vaccine strain.Semantic proximity Read ↗

Non-toxic derivatives of LT as potent adjuvants.Semantic proximity Read ↗

Host Functional Response to a Prototypic Orally Delivered Self-Replicating Vaccine PlatformSemantic proximity Read ↗

Designing a multi-epitopic vaccine against the enterotoxigenic Bacteroides fragilis based on immunoinformatics approachSemantic proximity Read ↗

Bioinformatics analysis to design a multi-epitope mRNA vaccine against S. agalactiae exploiting pathogenic proteinsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.