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Article

IKK-beta links inflammation to obesity-induced insulin resistance.

Nature medicine - 1 Feb 2005

Arkan Melek C, Hevener Andrea L, Greten Florian R, Maeda Shin, Li Zhi-Wei, Long Jeffrey M, Wynshaw-Boris Anthony, Poli Giuseppe, Olefsky Jerrold, Karin Michael

Abstract excerpt

Inflammation may underlie the metabolic disorders of insulin resistance and type 2 diabetes. IkappaB kinase beta (IKK-beta, encoded by Ikbkb) is a central coordinator of inflammatory responses through activation of NF-kappaB. To understand the role of IKK-beta in insulin resistance, we used mice lacking this enzyme in hepatocytes (Ikbkb(Deltahep)) or myeloid cells (Ikbkb(Deltamye)). Ikbkb(Deltahep) mice retain...

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PMID: 15685170
DOI: 10.1038/nm1185

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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