Article
Vps41 phosphorylation and the Rab Ypt7 control the targeting of the HOPS complex to endosome-vacuole fusion sites.
Molecular biology of the cell - 1 Apr 2009
Cabrera Margarita, Ostrowicz Clemens W, Mari Muriel, LaGrassa Tracy J, Reggiori Fulvio, Ungermann Christian
Abstract excerpt
Membrane fusion depends on multisubunit tethering factors such as the vacuolar HOPS complex. We previously showed that the vacuolar casein kinase Yck3 regulates vacuole biogenesis via phosphorylation of the HOPS subunit Vps41. Here, we link the identified Vps41 phosphorylation site to HOPS function at the endosome-vacuole fusion site. The nonphosphorylated Vps41 mutant (Vps41 S-A) accumulates together with other...
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