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Article

The molecular mechanisms underlying BiP-mediated gating of the Sec61 translocon of the endoplasmic reticulum.

The Journal of cell biology - 31 Jan 2005

Alder Nathan N, Shen Ying, Brodsky Jeffrey L, Hendershot Linda M, Johnson Arthur E

Abstract excerpt

The Sec61 translocon of the endoplasmic reticulum membrane forms an aqueous pore that is gated by the lumenal Hsp70 chaperone BiP. We have explored the molecular mechanisms governing BiP-mediated gating activity, including the coupling between gating and the BiP ATPase cycle, and the involvement of the substrate-binding and J domain-binding regions of BiP. Translocon gating was assayed by measuring the...

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Share to Adenosine Diphosphate
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15684029
DOI: 10.1083/jcb.200409174
PMCID: PMC2171714

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The molecular mechanisms underlying BiP-mediated gating of the Sec61 translocon of the endoplasmic reticulum.PMID 15684029Read ↗

Binding of secretory precursor polypeptides to a translocon subcomplex is regulated by BiP.Semantic proximity Read ↗

Specific molecular chaperone interactions and an ATP-dependent conformational change are required during posttranslational protein translocation into the yeast ER.Semantic proximity Read ↗

J domain co-chaperone specificity defines the role of BiP during protein translocation.Semantic proximity Read ↗

Translocation of proteins through the Sec61 and SecYEG channels.Semantic proximity Read ↗

In vivo analysis of the lumenal binding protein (BiP) reveals multiple functions of its ATPase domain.Semantic proximity Read ↗

Two alternative binding mechanisms connect the protein translocation Sec71-Sec72 complex with heat shock proteins.Semantic proximity Read ↗

Dynamic action of the Sec machinery during initiation, protein translocation and termination.Semantic proximity Read ↗

Regulated interactions of mtHsp70 with Tim44 at the translocon in the mitochondrial inner membrane.Semantic proximity Read ↗

Sec61p serves multiple roles in secretory precursor binding and translocation into the endoplasmic reticulum membrane.Semantic proximity Read ↗

Multistep mechanism of substrate binding determines chaperone activity of Hsp70.Semantic proximity Read ↗

ADP ribosylation adapts an ER chaperone response to short-term fluctuations in unfolded protein load.Semantic proximity Read ↗

Quaternary dynamics of the SecA motor drive translocase catalysis.Semantic proximity Read ↗

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