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Long HIV Type 1 Reverse Transcripts Can Accumulate Stably within Resting CD4 <sup>+</sup> T Cells While Short Ones Are Degraded

1 Mar 2004

Abstract excerpt

We utilized quantitative methods to compare the efficiency of reverse transcription and stability of viral DNA within resting and activated T cells. Highly purified resting CD4(+) T cells and activated T cells from healthy donors were spinoculated with HIV-1(YU-2), then cultured in conditions that maintain both the viability and the quiescence of the resting cells. Spreading infection was suppressed, then kinetic...

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PMID: 15117452
DOI: 10.1089/088922204322996527

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