Monorail/Foxa2 regulates floorplate differentiation and specification of oligodendrocytes, serotonergic raphé neurones and cranial motoneurones.

doi:10.1242/dev.01611

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Article

Monorail/Foxa2 regulates floorplate differentiation and specification of oligodendrocytes, serotonergic raphé neurones and cranial motoneurones.

Development (Cambridge, England) - 1 Feb 2005

Norton Will H, Mangoli Maryam, Lele Zsolt, Pogoda Hans-Martin, Diamond Brianne, Mercurio Sara, Russell Claire, Teraoka Hiroki, Stickney Heather L, Rauch Gerd-Jörg, Heisenberg Carl-Philipp, Houart Corinne, Schilling Thomas F, Frohnhoefer Hans-Georg, Rastegar Sepand, Neumann Carl J, Gardiner R Mark, Strähle Uwe, Geisler Robert, Rees Michelle, Talbot William S, Wilson Stephen W

Abstract excerpt

In this study, we elucidate the roles of the winged-helix transcription factor Foxa2 in ventral CNS development in zebrafish. Through cloning of monorail (mol), which we find encodes the transcription factor Foxa2, and phenotypic analysis of mol-/- embryos, we show that floorplate is induced in the absence of Foxa2 function but fails to further differentiate. In mol-/- mutants, expression of Foxa and Hh family...

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Identifiers

PMID: 15677724
DOI: 10.1242/dev.01611
PMCID: PMC2790417

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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