Article
Noradrenergic neurons in the zebrafish hindbrain are induced by retinoic acid and require tfap2a for expression of the neurotransmitter phenotype.
Development (Cambridge, England) - 1 Dec 2003
Holzschuh Jochen, Barrallo-Gimeno Alejandro, Ettl Anne-Kathrin, Durr Katrin, Knapik Ela W, Driever Wolfgang
Abstract excerpt
Tfap2a is a transcriptional activator expressed in many different cell types, including neurons, neural crest derivatives and epidermis. We show that mutations at the zebrafish locus previously called mont blanc (mob) or lockjaw (low) encode tfap2a. The mutant phenotype reveals that tfap2a is essential for the development of hindbrain noradrenergic (NA) neurons of the locus coeruleus, medulla and area postrema,...
Topics
- Adrenergic alpha-Agonists
- Animals
- Cell Differentiation
- Cloning, Molecular
- DNA-Binding Proteins
- Embryonic Induction
- Female
- Ganglia, Sympathetic
- Homeodomain Proteins
- In Situ Hybridization
- Male
- Nerve Tissue Proteins
- Neurons