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Article

Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells

1 Nov 1998

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Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 9817205
DOI: 10.1038/23962

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Related research

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Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cellsPMID 9817205Read ↗

Genetic and Epigenetic Changes in Human Epithelial Cells Immortalized by TelomeraseSemantic proximity Read ↗

Expression of hTERT immortalises normal human urothelial cells without inactivation of the p16/Rb pathwaySemantic proximity Read ↗

Telomerase induces immortalization of human esophageal keratinocytes without p16INK4a inactivation.Semantic proximity Read ↗

Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics.Semantic proximity Read ↗

Human ovarian surface epithelial cells immortalized with hTERT maintain functional pRb and p53 expressionSemantic proximity Read ↗

The significance of telomerase activation and cellular immortalization in human cancerSemantic proximity Read ↗

p16INK4a and the control of cellular proliferative life spanSemantic proximity Read ↗

Rb deficiency accelerates progression of carcinoma of the urinary bladder in vivo and in vitro through inhibiting autophagy and apoptosis.Semantic proximity Read ↗

Immortalization of human small airway epithelial cells by ectopic expression of telomeraseSemantic proximity Read ↗

Alterations in the p16(INK4a) and p53 tumor suppressor genes of hTERT-immortalized human fibroblasts.Semantic proximity Read ↗

The Role of p16INK4a Pathway in Human Epidermal Stem Cell Self-Renewal, Aging and CancerSemantic proximity Read ↗

Human telomerase accelerates growth of lens epithelial cells through regulation of the genes mediating RB/E2F pathwaySemantic proximity Read ↗

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