Article
Epigenetic and genetic alterations of p33ING1b in ovarian cancer.
Carcinogenesis - 1 Apr 2005
Shen Dan-Hua, Chan Kelvin Yuen-Kwong, Khoo Ui-Soon, Ngan Hextan Yuen-Sheung, Xue Wei-Cheng, Chiu Pui-Man, Ip Philip, Cheung Annie Nga-Yin
Abstract excerpt
p33ING1b is a candidate tumor suppressor gene and a nuclear protein. We investigated whether genetic and epigenetic mechanisms affect p33ING1b expression in ovarian cancer thus contributing toward its pathogenesis. A total of 111 ovarian cancers collected from Beijing and Hong Kong were used for this study. Weak or negative p33ING1b protein expression was demonstrated by immunohistochemistry on tissue microarray...
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