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Article

Downregulation of nuclear expression of the p33 <sup>ING1b</sup> inhibitor of growth protein in invasive carcinoma of the breast

30 Jun 2003

Abstract excerpt

BACKGROUND/AIMS: The inhibitor of growth gene 1 (ING1) is a modulator of cell cycle checkpoints, apoptosis, and cellular senescence. The most widely expressed ING1 isoform is p33(ING1b), which can modulate p53, a molecule that is frequently altered in breast cancer. Reduced ING1 mRNA expression has been observed in primary breast cancer expressing wild-type p53. METHODS: p33(ING1b), p53, oestrogen receptor (ER),...

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PMID: 12835295
DOI: 10.1136/jcp.56.7.507

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Downregulation of nuclear expression of the p33 <sup>ING1b</sup> inhibitor of growth protein in invasive carcinoma of the breastPMID 12835295Read ↗

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