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Article

A hot spot for hotfoot mutations in the gene encoding the delta2 glutamate receptor.

The European journal of neuroscience - 1 Apr 2003

Wang Ying, Matsuda Shinji, Drews Valerie, Torashima Takashi, Meisler Miriam H, Yuzaki Michisuke

Abstract excerpt

The orphan glutamate receptor delta2 is selectively expressed in Purkinje cells and plays a crucial role in cerebellar functions. Recently, ataxia in the hotfoot mouse ho4J was demonstrated to be caused by a deletion in the delta2 receptor gene (Grid2) removing the N-terminal 170 amino acids of the delta2 receptor. To understand how delta2 receptors function, we characterized mutations in eight additional...

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Source

Identifiers

PMID: 12752376
DOI: 10.1046/j.1460-9568.2003.02595.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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