Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Detection of a complex chromosomal rearrangement in a novel mouse mutant by optical genome mapping.

Mammalian genome : official journal of the International Mammalian Genome Society - 13 Jun 2026

Holtgrefe Gretchen, Wight Patricia A

Abstract excerpt

Here we highlight the utilities of optical genome mapping (OGM) in determining the genomic rearrangements present in a novel transgenic mouse line (Line 781), which expresses the bacterial lacZ reporter gene under control of the mouse myelin proteolipid protein (Plp1) promoter. Hemizygous transgenic mice from Line 781 present with a mutant phenotype (documented here) which entails small body size and paws and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosome Aberrations
Share to Chromosome Mapping

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mice, Transgenic

Share to Mutation

Share to Myelin Proteolipid Protein

Share to Phenotype

Share to Translocation, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 42287466
DOI: 10.1007/s00335-026-10241-4
PMCID: PMC13264541

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 16 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Detection of a complex chromosomal rearrangement in a novel mouse mutant by optical genome mapping.PMID 42287466Read ↗

Detection of a complex chromosomal rearrangement in a novel mouse mutant by optical genome mappingSemantic proximity Read ↗

A transgenic insertional inner ear mutation on mouse chromosome 1.Semantic proximity Read ↗

Induced mouse chromosomal rearrangements as tools for identifying critical developmental genes and pathways.Semantic proximity Read ↗

The mouse genome: an overview.Semantic proximity Read ↗

Detection of complex chromosome rearrangements using optical genome mappingSemantic proximity Read ↗

Comparative genetic mapping for the identification of novel diagnostic and therapeutic targets.Semantic proximity Read ↗

Identification and applications of repetitive probes for gene mapping in the mouse.Semantic proximity Read ↗

Mapping the mouse genome: current status and future prospects.Semantic proximity Read ↗

Genetic mapping of the mouse genome.Semantic proximity Read ↗

Gait abnormalities and progressive myelin degeneration in a new murine model of Pelizaeus-Merzbacher disease with tandem genomic duplication.Semantic proximity Read ↗

High-resolution genetic map of mouse chromosome 1 between D1Mit227 and D1Mit15 by use of an intercross of C57BL/6J x C3HeB/FeJ vl/vl.Semantic proximity Read ↗

Elevated presence of retrotransposons at sites of DNA double strand break repair in mouse models of metabolic oxidative stress and MYC-induced lymphoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.