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Susceptibility to bystander DNA damage is influenced by replication and transcriptional activity

31 Aug 2012

Abstract excerpt

Direct cellular DNA damage may lead to genome destabilization in unexposed, bystander, cells sharing the same milieu with directly damaged cells by means of the bystander effect. One proposed mechanism involves double strand break (DSB) formation in S phase cells at sites of single strand lesions in the DNA of replication complexes, which has a more open structure compared with neighboring DNA. The DNA in...

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PMID: 22941641
DOI: 10.1093/nar/gks795

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