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Article

Tumor TP53 expression status, body mass index and prognosis in colorectal cancer.

International journal of cancer - 1 Sept 2012

Morikawa Teppei, Kuchiba Aya, Liao Xiaoyun, Imamura Yu, Yamauchi Mai, Qian Zhi Rong, Nishihara Reiko, Sato Kaori, Meyerhardt Jeffrey A, Fuchs Charles S, Ogino Shuji

Abstract excerpt

Inactivation of the TP53 (p53) pathway by TP53 mutations is one of key steps in colorectal carcinogenesis. TP53 also plays an important role in cellular energy metabolism. We hypothesized that TP53-altered tumor cells might behave aggressively independent of energy balance, while progression of TP53-intact cells might depend on excess energy balance. Utilizing a database of 1,060 colon and rectal cancer patients...

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PMID: 22038927
DOI: 10.1002/ijc.26495
PMCID: PMC3288809

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