Article
Common BRCA2 variants and modification of breast and ovarian cancer risk in BRCA1 mutation carriers.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jan 2005
Hughes David J, Ginolhac Sophie M, Coupier Isabelle, Corbex Marilys, Bressac-de-Paillerets Brigitte, Chompret Agnès, Bignon Yves-Jean, Uhrhammer Nancy, Lasset Christine, Giraud Sophie, Hardouin Agnès, Berthet Pascaline, Peyrat Jean-Philippe, Fournier Joelle, Nogues Catherine, Lidereau Rosette, Muller Danièle, Fricker Jean-Pierre, Longy Michel, Toulas Christine, Guimbaud Rosine, Maugard Christine, Olschwang Sylviane, Yannoukakos Drakoulis, Durocher Francine, Moisan Anne-Marie, Simard Jacques, Mazoyer Sylvie, Lynch Henry T, Szabo Csilla, Lenoir Gilbert M, Goldgar David E, Stoppa-Lyonnet Dominique, Sinilnikova Olga M
Abstract excerpt
The HH genotype of the nonconservative amino acid substitution polymorphism N372H in the BRCA2 gene was reported to be associated with a 1.3- to 1.5-fold increase in risk of both breast and ovarian cancer. As these studies concerned sporadic cancer cases, we investigated whether N372H and another common variant located in the 5'-untranslated region (203G > A) of the BRCA2 gene modify breast or ovarian cancer risk...
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