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Disease family history and modification of breast cancer risk in common BRCA2 variants.

Oncology reports - 1 Mar 2008

Seymour Ian Jonathan, Casadei Silvia, Zampiga Valentina, Rosato Simonetta, Danesi Rita, Falcini Fabio, Strada Miria, Morini Nori, Naldoni Carlo, Paradiso Angelo, Tommasi Stefania, Schittulli Francesco, Amadori Dino, Calistri Daniele

Abstract excerpt

A number of BRCA1 and BRCA2 polymorphisms have been extensively studied in order to test their association with breast cancer risk. Subsequently, discordant results were reported. In the present study, the genotypes of one BRCA1 (Q356R) and three BRCA2 (203G>A, N372H, IVS21-66T>C) common variants were evaluated in a series of 252 breast cancer patients, 155 age-matched controls and analysed in relation to family...

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Identifiers

PMID: 18288416

Genes

BRCA1
BRCA2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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