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Article

Polymorphisms in BRCA1 and BRCA2 and risk of epithelial ovarian cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Oct 2003

Wenham Robert M, Schildkraut Joellen M, McLean Kia, Calingaert Brian, Bentley Rex C, Marks Jeffrey, Berchuck Andrew

Abstract excerpt

PURPOSE: Because inherited BRCA1 or BRCA2 mutations strikingly increase ovarian cancer risk, polymorphisms in these genes could represent low penetrance susceptibility alleles. Previous studies of the BRCA2 N372H polymorphism suggested that HH homozygotes have a modestly increased risk of both breast and ovarian cancer. We have examined whether BRCA2 N372H or common amino acid-changing polymorphisms in BRCA1...

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Source

Identifiers

PMID: 14555511

Genes

BRCA1
BRCA2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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