Article
Association between the BRCA2 N372H variant and male breast cancer risk: a population-based case-control study in Tuscany, Central Italy.
BMC cancer - 3 Sept 2007
Palli Domenico, Falchetti Mario, Masala Giovanna, Lupi Ramona, Sera Francesco, Saieva Calogero, D'Amico Cristina, Ceroti Marco, Rizzolo Piera, Caligo Maria Adelaide, Zanna Ines, Ottini Laura
Abstract excerpt
BACKGROUND: Male breast cancer (MBC) is a rare disease and little is known about its aetiology. Germ-line mutations of BRCA2 and, at lower frequency, of BRCA1 are implicated in a relatively small proportion of MBC cases. Common polymorphic variants in BRCA1 and BRCA2 genes may represent breast cancer (BC) susceptibility alleles and could be associated with a modestly increased risk of MBC at population level....
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