Article
Pradimicin resistance of yeast is caused by a mutation of the putative N-glycosylation sites of osmosensor protein Sln1.
Bioscience, biotechnology, and biochemistry - 1 Jan 2005
Hiramoto Fumitaka, Nomura Nobuhiko, Furumai Tamotsu, Igarashi Yasuhiro, Oki Toshikazu
Abstract excerpt
Pradimicin, a mannose-binding antifungal antibiotic, induces apoptosis-like cell death in Saccharomyces cerevisiae. Previously we found that the substitution of the 74th amino acid from glycine to cysteine in Ypd1 yields a mutant resistant to pradimicin. In this study, the involvement of a membrane-spanning osomosensor, Sln1, which is located upstream of Ypd1, was investigated. A mutant, sln1 DeltaNG, that lacks...
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