Article
MNL1 regulates weak acid-induced stress responses of the fungal pathogen Candida albicans.
Molecular biology of the cell - 1 Oct 2008
Ramsdale Mark, Selway Laura, Stead David, Walker Jan, Yin Zhikang, Nicholls Susan M, Crowe Jonathan, Sheils Emma M, Brown Alistair J P
Abstract excerpt
MNL1, the Candida albicans homologue of an orphan Msn2-like gene (YER130c in Saccharomyces cerevisiae) has no known function. Here we report that MNL1 regulates weak acid stress responses. Deletion of MNL1 prevents the long-term adaptation of C. albicans cells to weak acid stresses and compromises their global transcriptional response under these conditions. The promoters of Mnl1-dependent genes contain a novel...
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