Article
Role of the mitogen-activated protein kinase Hog1p in morphogenesis and virulence of Candida albicans.
Journal of bacteriology - 1 May 1999
Alonso-Monge R, Navarro-García F, Molero G, Diez-Orejas R, Gustin M, Pla J, Sánchez M, Nombela C
Abstract excerpt
The relevance of the mitogen-activated protein (MAP) kinase Hog1p in Candida albicans was addressed through the characterization of C. albicans strains without a functional HOG1 gene. Analysis of the phenotype of hog1 mutants under osmostressing conditions revealed that this mutant displays a set of morphological alterations as the result of a failure to complete the final stages of cytokinesis, with parallel...
Topics
- Animals
- Antifungal Agents
- Blood Proteins
- Brain
- Calcium-Calmodulin-Dependent Protein Kinases
- Candida albicans
- Candidiasis
- Cell Wall
- Chitinases
- Congo Red
- Gene Deletion
- Genes, Fungal
- Genetic Predisposition to Disease