Article
The matrix metalloproteinase-3 (MMP-3) 5A/6A promoter polymorphism is not associated with ischaemic heart disease: analysis employing a family based approach.
Disease markers - 1 Jan 2004
McGlinchey Paul G, Spence Mark S, Patterson Chris C, Allen Adrian R, Murphy Gillian, Fogarty Damian, Evans Alun, McKeown Pascal P
Abstract excerpt
Matrix metalloproteinase-3 (MMP-3) has been proposed as an important mediator of the atherosclerotic process. The possible role of the functional -1612 5A/6A polymorphism of the MMP-3 gene in the susceptibility to ischaemic heart disease (IHD) was investigated in a well-defined Irish population using two recently described family based tests of association. One thousand and twelve individuals from 386 families...
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