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Article

HLA haplotypes and TNF polymorphism do not associate with longevity in the Irish.

Mechanisms of ageing and development - 1 Apr 2003

Ross Owen A, Curran Martin D, Rea I Maeve, Hyland Paul, Duggan Orla, Barnett Christopher R, Annett Kathryn, Patterson Chris, Barnett Yvonne A, Middleton Derek

Abstract excerpt

Polymorphism of the human leukocyte antigen has been implicated in a number of autoimmune disorders including ageing. In the course of the present study, no association of the human leukocyte antigen (HLA)-A1, B8, DR3 haplotype with a male Irish aged population, as previously reported, was observed. Two polymorphic nucleotides in the TNF cluster (G-308A TNF-alpha and G+252A TNF-beta), associated with increased...

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Source

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PMID: 12714268
DOI: 10.1016/s0047-6374(03)00037-x

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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