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Article

The diversity of dolichol-linked precursors to Asn-linked glycans likely results from secondary loss of sets of glycosyltransferases.

Proceedings of the National Academy of Sciences of the United States of America - 1 Feb 2005

Samuelson John, Banerjee Sulagna, Magnelli Paula, Cui Jike, Kelleher Daniel J, Gilmore Reid, Robbins Phillips W

Abstract excerpt

The vast majority of eukaryotes (fungi, plants, animals, slime mold, and euglena) synthesize Asn-linked glycans (Alg) by means of a lipid-linked precursor dolichol-PP-GlcNAc2Man9Glc3. Knowledge of this pathway is important because defects in the glycosyltransferases (Alg1-Alg12 and others not yet identified), which make dolichol-PP-glycans, lead to numerous congenital disorders of glycosylation. Here we used...

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PMID: 15665075
DOI: 10.1073/pnas.0409460102
PMCID: PMC545090

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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