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Phylogenomic Analyses of Nucleotide-Sugar Biosynthetic and Interconverting Enzymes Illuminate Cell Wall Composition in Fungi.

mBio - 13 Apr 2021

Schwerdt Julian, Qiu Hao, Shirley Neil, Little Alan, Bulone Vincent

Abstract excerpt

The fungi are an enormously successful eukaryotic lineage that has colonized every aerobic habitat on Earth. This spectacular expansion is reflected in the dynamism and diversity of the fungal cell wall, a matrix of polysaccharides and glycoproteins pivotal to fungal life history strategies and a major target in the development of antifungal compounds. Cell wall polysaccharides are typically synthesized by Leloir...

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PMID: 33849982
DOI: 10.1128/mBio.03540-20
PMCID: PMC8092308

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